Auxiliary-assisted palladium-catalyzed arylation and alkylation of sp2 and sp3 carbon-hydrogen bonds.

@article{Shabashov2010AuxiliaryassistedPA,
  title={Auxiliary-assisted palladium-catalyzed arylation and alkylation of sp2 and sp3 carbon-hydrogen bonds.},
  author={Dmitry Shabashov and Olafs Daugulis},
  journal={Journal of the American Chemical Society},
  year={2010},
  volume={132 11},
  pages={3965-72}
}
We have developed a method for auxiliary-directed, palladium-catalyzed beta-arylation and alkylation of sp(3) and sp(2) C-H bonds in carboxylic acid derivatives. The method employs a carboxylic acid 2-methylthioaniline- or 8-aminoquinoline amide substrate, aryl or alkyl iodide coupling partner, palladium acetate catalyst, and an inorganic base. By employing… CONTINUE READING