Autoxidation of gallic acid induces ROS-dependent death in human prostate cancer LNCaP cells.

@article{Russell2012AutoxidationOG,
  title={Autoxidation of gallic acid induces ROS-dependent death in human prostate cancer LNCaP cells.},
  author={Larry H Russell and Elizabeth A. Mazzio and Ramesh Babu Badisa and Zhi-ping Zhu and Maryam Agharahimi and Ebenezer T. Oriaku and Carl B. Goodman},
  journal={Anticancer research},
  year={2012},
  volume={32 5},
  pages={1595-602}
}
BACKGROUND Prostate cancer is the second most common cause of mortality. Gallic acid (GA) is a natural polyphenol, and we tested its in-vitro cytotoxicity after 24 h in prostate cancer LNCaP cells. MATERIALS AND METHODS GA autoxidation was measured fluorimetrically for H(2)O(2), and O(2)(•-) radicals by chemiluminescence. Intracellular reactive oxygen species (ROS) levels were detected with 2',7'-dichlorodihydrofluorescein diacetate. Cytotoxicity was evaluated by crystal-violet, while… CONTINUE READING
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