Autotransplant with and without induction chemotherapy in older multiple myeloma patients: long-term outcome of a randomized trial.

@article{Straka2016AutotransplantWA,
  title={Autotransplant with and without induction chemotherapy in older multiple myeloma patients: long-term outcome of a randomized trial.},
  author={Christian Straka and Peter Liebisch and Hans J{\"u}rgen Salwender and Burkhard Hennemann and Bernd Metzner and Stefan Knop and Sigrid Adler-Reichel and Christian Gerecke and Hannes Wandt and Martin Bentz and Tim Hendrik Bruemmendorf and Marcus Hentrich and Michael Pfreundschuh and H H Wolf and Orhan Sezer and Ralf C Bargou and Wolfram Jung and Lorenz H. Tr{\"u}mper and Bernd Hertenstein and Else Heidemann and H. Christian Bernhard and Nicola Lang and Norbert Frickhofen and Holger F. Hebart and Ralf Schmidmaier and Andreas Sandermann and Tobias Dechow and Albrecht Reichle and Brigitte Schnabel and Kerstin Schaefer-Eckart and Christian Langer and Martin Gramatzki and Axel Hinke and Bertold Emmerich and Hermann Einsele},
  journal={Haematologica},
  year={2016},
  volume={101 11},
  pages={1398-1406}
}
Autologous transplantation is controversial for older patients with multiple myeloma. The role of age-adjusted high-dose melphalan and the impact of induction chemotherapy cycles is still unclear. A total of 434 patients aged 60-70 years were randomly assigned to 4 cycles of standard anthracycline-based induction chemotherapy or no induction. For all patients, double autologous transplantation after melphalan 140 mg/m2 (MEL140) was planned. The primary end point was progression-free survival… CONTINUE READING
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Older patients with myeloma derive similar benefit from autologous transplantation.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation • 2014

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