Autotaxin through lysophosphatidic acid stimulates polarization, motility, and transendothelial migration of naive T cells.

@article{Zhang2012AutotaxinTL,
  title={Autotaxin through lysophosphatidic acid stimulates polarization, motility, and transendothelial migration of naive T cells.},
  author={Yafeng Zhang and Yi-Chun Chen and Matthew F Krummel and S D Rosen},
  journal={Journal of immunology},
  year={2012},
  volume={189 8},
  pages={3914-24}
}
Blood-borne lymphocytes home to lymph nodes by interacting with and crossing high endothelial venules (HEVs). The transendothelial migration (TEM) step is poorly understood. Autotaxin (ATX) is an ectoenzyme that catalyzes the conversion of lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA), a bioactive lipid and a close relative of sphingosine 1-phosphate. HEVs produce and secrete ATX into the blood. A prior study implicated ATX in the overall homing process, but the step in which it… CONTINUE READING
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