Autotaxin regulates vascular development via multiple lysophosphatidic acid (LPA) receptors in zebrafish.

@article{Yukiura2011AutotaxinRV,
  title={Autotaxin regulates vascular development via multiple lysophosphatidic acid (LPA) receptors in zebrafish.},
  author={Hiroshi Yukiura and Kotaro Hama and Keita Nakanaga and Masayuki Tanaka and Yoichi Asaoka and Shinichi Okudaira and Naoaki Arima and Asuka Inoue and Takafumi Hashimoto and Hiroyuki Arai and Atsuo Kawahara and Hiroshi Nishina and Junken Aoki},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 51},
  pages={
          43972-83
        }
}
Autotaxin (ATX) is a multifunctional ecto-type phosphodiesterase that converts lysophospholipids, such as lysophosphatidylcholine, to lysophosphatidic acid (LPA) by its lysophospholipase D activity. LPA is a lipid mediator with diverse biological functions, most of which are mediated by G protein-coupled receptors specific to LPA (LPA1-6). Recent studies on ATX knock-out mice revealed that ATX has an essential role in embryonic blood vessel formation. However, the underlying molecular… CONTINUE READING
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