Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production

@article{UmezuGoto2002AutotaxinHL,
  title={Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production},
  author={Makiko Umezu-Goto and Yasuhiro Kishi and Akitsu Taira and Kotaro Hama and Naoshi Dohmae and Koji Takio and Takao Yamori and Gordon B. Mills and Keizo Inoue and Junken Aoki and Hiroyuki Arai},
  journal={The Journal of Cell Biology},
  year={2002},
  volume={158},
  pages={227 - 233}
}
Autotaxin (ATX) is a tumor cell motility-stimulating factor, originally isolated from melanoma cell supernatants. ATX had been proposed to mediate its effects through 5'-nucleotide pyrophosphatase and phosphodiesterase activities. However, the ATX substrate mediating the increase in cellular motility remains to be identified. Here, we demonstrated that lysophospholipase D (lysoPLD) purified from fetal bovine serum, which catalyzes the production of the bioactive phospholipid mediator… CONTINUE READING
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New water-soluble hydrogen donors for the enzymatic photometric determination of hydrogen peroxide

  • K. Tamaoku, K. Ueno, K. Akiura, Y. Ohkura.
  • Chem. Pharm. Bull. 30:2492–2497.
  • 1982
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