Autotaxin–Lysophosphatidic Acid Signaling in Alzheimer’s Disease

@inproceedings{Ramesh2018AutotaxinLysophosphatidicAS,
  title={Autotaxin–Lysophosphatidic Acid Signaling in Alzheimer’s Disease},
  author={Sindhu Ramesh and Manoj Y. Govindarajulu and Vishnu Suppiramaniam and Timothy Moore and Muralikrishnan Dhanasekaran},
  booktitle={International journal of molecular sciences},
  year={2018}
}
The brain contains various forms of lipids that are important for maintaining its structural integrity and regulating various signaling cascades. Autotaxin (ATX) is an ecto-nucleotide pyrophosphatase/phosphodiesterase-2 enzyme that hydrolyzes extracellular lysophospholipids into the lipid mediator lysophosphatidic acid (LPA). LPA is a major bioactive lipid which acts through G protein-coupled receptors (GPCRs) and plays an important role in mediating cellular signaling processes. The majority… CONTINUE READING

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