Autosomal recessive inheritance of airway hyperreactivity to 5-hydroxytryptamine.

@article{Levitt1989AutosomalRI,
  title={Autosomal recessive inheritance of airway hyperreactivity to 5-hydroxytryptamine.},
  author={Roy C Levitt and Wayne Mitzner},
  journal={Journal of applied physiology},
  year={1989},
  volume={67 3},
  pages={
          1125-32
        }
}
We have previously reported that airway hyperresponsiveness to acetylcholine (ACh) is inherited as an autosomal recessive trait in A/J and C3H/HeJ mice and the progeny of crosses between them (FASEB J. 2: 2605-2608, 1988). In the present report, we have extended these studies by evaluating the biological variability in the airway response to 5-hydroxytryptamine (5-HT) and ACh among multiple genetically standardized inbred strains of mice. The pattern of airway responsiveness to ACh differed… CONTINUE READING
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