Autosomal gsdf acts as a male sex initiator in the fish medaka.

@article{Zhang2016AutosomalGA,
  title={Autosomal gsdf acts as a male sex initiator in the fish medaka.},
  author={Xi Zhang and Guijun Guan and Mingyou Li and Feng Zhu and Qizhi Liu and Kiyoshi Naruse and Amaury Herpin and Yoshitaka Nagahama and Jia-le Li and Yunhan Hong},
  journal={Scientific reports},
  year={2016},
  volume={6},
  pages={19738}
}
Sex is pivotal for reproduction, healthcare and evolution. In the fish medaka, the Y-chromosomal dmy (also dmrt1bY) serves the sex determiner, which activates dmrt1 for male sex maintenance. However, how dmy makes the male decision via initiating testicular differentiation has remained unknown. Here we report that autosomal gsdf serves a male sex initiator. Gene addition and deletion revealed that gsdf was necessary and sufficient for maleness via initiating testicular differentiation. We show… CONTINUE READING
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