Autosomal dominant transmission of gouty arthritis with renal disease in a large Japanese family.

@article{Yokota1991AutosomalDT,
  title={Autosomal dominant transmission of gouty arthritis with renal disease in a large Japanese family.},
  author={N Yokota and H Yamanaka and Y Yamamoto and S Fujimoto and T Eto and K Tanaka},
  journal={Annals of the rheumatic diseases},
  year={1991},
  volume={50 2},
  pages={108-11}
}
  • N Yokota, H Yamanaka, +3 authors K Tanaka
  • Published 1991 in Annals of the rheumatic diseases
Six generations of a Japanese family had gouty arthritis and progressive nephropathy. Data on nine of 51 women (18%) and 15 of 66 men (23%) with either asymptomatic hyperuricaemia, gouty arthritis, or renal insufficiency were obtained. Renal function in four men and one woman with hyperuricaemia or gouty arthritis was also examined. Urinary excretion of uric acid was decreased in all subjects examined, including the young. Erythrocyte phosphoribosylpyrophosphate synthetase and hypoxanthine… CONTINUE READING