Autosomal dominant transmission of autoantibodies to thyroglobulin and thyroid peroxidase.

@article{Phillips1990AutosomalDT,
  title={Autosomal dominant transmission of autoantibodies to thyroglobulin and thyroid peroxidase.},
  author={David W. Phillips and Sue-Anne Mclachlan and Angela Stephenson and David Roberts and Stephen Moffitt and David McDonald and A H Ad'hiah and A. Maurice Stratton and Elizabeth C. Young and F Y Clark},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1990},
  volume={70 3},
  pages={742-6}
}
The inheritance of autoantibodies to thyroglobulin and thyroid peroxidase (thyroid microsomal antigen) has been reevaluated with newly developed ultrasensitive assays that depend on the direct interaction between antibody and radiolabeled antigen. In a study of 16 families with autoimmune thyroid disease, autoantibodies to thyroid peroxidase (TPO) were found to be inherited as a dominant Mendelian trait in females with reduced penetrance in males. Similar results were obtained with… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

Similar Papers

Loading similar papers…