Autosomal dominant retinitis pigmentosa: linkage to rhodopsin and evidence for genetic heterogeneity.

@article{Farrar1990AutosomalDR,
  title={Autosomal dominant retinitis pigmentosa: linkage to rhodopsin and evidence for genetic heterogeneity.},
  author={G. Jane Farrar and Peter McWilliam and Daniel G Bradley and Paul F. Mc Kenna and Mark E. Lawler and Elizabeth M. Sharp and Marian M. Humphries and Hans Eiberg and P. Michael Conneally and James A. Trofatter},
  journal={Genomics},
  year={1990},
  volume={8 1},
  pages={35-40}
}
Retinitis pigmentosa (RP) is the most prevalent human retinopathy of genetic origin. Chromosomal locations for X-linked RP and autosomal dominant RP genes have recently been established. Multipoint analyses with ADRP and seven markers on the long arm of chromosome 3 demonstrate that the gene for rhodopsin, the pigment of the rod photoreceptors, cosegregates with the disease locus with a maximum lod score of approximately 19, implicating rhodopsin as a causative gene. Recent studies have… CONTINUE READING
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