Autosomal dominant familial spastic paraplegia: tight linkage to chromosome 15q.

@article{Fink1995AutosomalDF,
  title={Autosomal dominant familial spastic paraplegia: tight linkage to chromosome 15q.},
  author={John K. Fink and C. Thomas Wu and Steven J. Jones and Gregory B. Sharp and B Markus Lange and A Lesicki and T Reinglass and Tena Varvil and B. Otterud and M. Leppert},
  journal={American journal of human genetics},
  year={1995},
  volume={56 1},
  pages={188-92}
}
Autosomal dominant, uncomplicated familial spastic paraplegia (FSP) is a genetically heterogeneous disorder characterized by insidiously progressive lower-extremity spasticity. Recently, a locus on chromosome 14q was shown to be tightly linked with the disorder in one of three families. We performed linkage analysis in a kindred with autosomal dominant uncomplicated FSP. After excluding the chromosome 14q locus, we observed tight linkage of the disorder to a group of markers on chromosome 15q… CONTINUE READING