Autosomal‐dominant locus for restless legs syndrome in French‐Canadians on chromosome 16p12.1

  title={Autosomal‐dominant locus for restless legs syndrome in French‐Canadians on chromosome 16p12.1},
  author={Anastasia Levchenko and Jacques Y. Montplaisir and G{\'e}raldine Asselin and Sylvie Provost and Simon L. Girard and Lan Xiong and Emmanuelle Lemyre and Judith St‐Onge and Pascale Thibodeau and Alex Desautels and Gustavo Turecki and Cl{\'a}udia Gaspar and Marie-Pierre Dub{\'e} and Guy A. Rouleau},
  journal={Movement Disorders},
We describe an autosomal‐dominant locus for Restless Legs Syndrome (RLS) in a French‐Canadian (FC) pedigree. Genome‐wide microsatellite scan and linkage analysis were used in this study. The locus maps to chromosome 16p12.1 and spans 1.18 Mega bases. The maximum multipoint LOD scores are of 3.5 over the total of 10 markers. Evidence for the same locus was also found in a smaller FC pedigree sime095. The analysis of the sequence of 8 annotated genes within the region did not reveal any… 

Autosomal dominant restless legs syndrome maps to chromosome 20p13 (RLS‐5) in a Dutch kindred

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Family‐based and population‐based association studies validate PTPRD as a risk factor for restless legs syndrome

  • Qinbo YangLin Li Q. Wang
  • Psychology, Biology
    Movement disorders : official journal of the Movement Disorder Society
  • 2011
This study used both family‐based and population‐based association studies to assess the association between PTPRD and RLS in an American Caucasian population.

Genetics of restless legs syndrome: An update.

MAPT1 gene rs1052553 variant is unrelated with the risk for restless legs syndrome

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Suggestive evidence for linkage for restless legs syndrome on chromosome 19p13

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The 14q restless legs syndrome locus in the French Canadian population

A new restless legs syndrome locus on chromosome 14 recently has been reported in one family of Italian origin, providing support for the existence of this locus and indicating thatThis locus may be responsible for a small fraction of French Canadian restless Legs syndrome.

Evidence for further genetic locus heterogeneity and confirmation of RLS‐1 in restless legs syndrome

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Family‐based association study of the restless legs syndrome loci 2 and 3 in a European population

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