Autosomal‐dominant locus for restless legs syndrome in French‐Canadians on chromosome 16p12.1

@article{Levchenko2009AutosomaldominantLF,
  title={Autosomal‐dominant locus for restless legs syndrome in French‐Canadians on chromosome 16p12.1},
  author={Anastasia Levchenko and Jacques Y. Montplaisir and G{\'e}raldine Asselin and Sylvie Provost and Simon L. Girard and Lan Xiong and Emmanuelle Lemyre and Judith St‐Onge and Pascale Thibodeau and Alex Desautels and Gustavo Turecki and Cl{\'a}udia Gaspar and Marie-Pierre Dub{\'e} and Guy A. Rouleau},
  journal={Movement Disorders},
  year={2009},
  volume={24}
}
We describe an autosomal‐dominant locus for Restless Legs Syndrome (RLS) in a French‐Canadian (FC) pedigree. Genome‐wide microsatellite scan and linkage analysis were used in this study. The locus maps to chromosome 16p12.1 and spans 1.18 Mega bases. The maximum multipoint LOD scores are of 3.5 over the total of 10 markers. Evidence for the same locus was also found in a smaller FC pedigree sime095. The analysis of the sequence of 8 annotated genes within the region did not reveal any… 
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