Autosomal, mitochondrial, and Y chromosome DNA variation in Finland: evidence for a male-specific bottleneck.

@article{Kittles1999AutosomalMA,
  title={Autosomal, mitochondrial, and Y chromosome DNA variation in Finland: evidence for a male-specific bottleneck.},
  author={Rick A Kittles and Andrew Bergen and M. Urbanek and Matti Virkkunen and Markku Linnoila and David Goldman and Jeffrey C. Long},
  journal={American journal of physical anthropology},
  year={1999},
  volume={108 4},
  pages={381-99}
}
The high prevalence of rare genetic diseases in Finland has been attributed to a founder effect some 2,000 years ago. However, this hypothesis has not been supported from mtDNA sequence and autosomal microsatellite data which indicate high levels of gene diversity. Here we have identified genetic evidence for a population bottleneck by examining variable microsatellite loci on the nonrecombining portion of Y chromosomes from Finland and four populations from Europe and the Americas. Sequence… CONTINUE READING