Autoshortloop feedback regulation of pulsatile gonadotropin-releasing hormone (GnRH) secretion by its metabolite, GnRH-(1–5)

@article{Larco2014AutoshortloopFR,
  title={Autoshortloop feedback regulation of pulsatile gonadotropin-releasing hormone (GnRH) secretion by its metabolite, GnRH-(1–5)},
  author={Darwin Omar Larco and Melissa Williams and Lauren Schmidt and Nick Sabel and Jason R Lange and Michael John Woller and Tao-yiao John Wu},
  journal={Endocrine},
  year={2014},
  volume={49},
  pages={470-478}
}
Given the central role of the decapeptide gonadotropin-releasing hormone (GnRH) in reproductive function, our long-term objective is to delineate the underlying mechanism regulating these reproductive processes. The outcome of GnRH secretion is in part dependent on the proteolytic metabolism of this decapeptide. In contrast to the belief that the metabolism of GnRH serves only as a degradative process that removes excess GnRH, we have shown that a metabolite of the decapeptide, GnRH-(1–5), can… CONTINUE READING