Autoregulatory loop and retinoic acid repression regulate pou2/pou5f1 gene expression in the zebrafish embryonic brain.

@article{Parvin2008AutoregulatoryLA,
  title={Autoregulatory loop and retinoic acid repression regulate pou2/pou5f1 gene expression in the zebrafish embryonic brain.},
  author={Mst. Shahnaj Parvin and Noriko Okuyama and Fumitaka Inoue and Md. Ekramul Islam Islam and Atsushi Kawakami and Hiroyuki Takeda and Kyo Yamasu},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2008},
  volume={237 5},
  pages={
          1373-88
        }
}
Zebrafish pou5f1, also known as pou2, encodes a POU-family transcription factor that is transiently expressed in the prospective midbrain and anterior hindbrain during gastrulation, governing brain development. In the present study, we found that the main regulatory elements reside in the proximal upstream DNA sequence from -2.2 to -0.12 kb (the -2.2/-0.1 region). The electrophoretic gel mobility shift assay (EMSA) revealed four functional octamer sequences that can associate with zebrafish… CONTINUE READING
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