Autoregulation of the mechanistic target of rapamycin (mTOR) complex 2 integrity is controlled by an ATP-dependent mechanism.

@article{Chen2013AutoregulationOT,
  title={Autoregulation of the mechanistic target of rapamycin (mTOR) complex 2 integrity is controlled by an ATP-dependent mechanism.},
  author={C Chen and Vladimir Kiyan and Assylbek A. Zhylkibayev and Dubek Kazyken and O. V. Bulgakova and Kent E Page and Rakhmet I Bersimbaev and Eric Spooner and Dos D. Sarbassov},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 38},
  pages={27019-30}
}
Nutrients are essential for living organisms because they fuel biological processes in cells. Cells monitor nutrient abundance and coordinate a ratio of anabolic and catabolic reactions. Mechanistic target of rapamycin (mTOR) signaling is the essential nutrient-sensing pathway that controls anabolic processes in cells. The central component of this pathway is mTOR, a highly conserved and essential protein kinase that exists in two distinct functional complexes. The nutrient-sensitive mTOR… CONTINUE READING
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