Autoregulation of the Escherichia coli melR promoter: repression involves four molecules of MelR

@inproceedings{Samarasinghe2008AutoregulationOT,
  title={Autoregulation of the Escherichia coli melR promoter: repression involves four molecules of MelR},
  author={Shivanthi Samarasinghe and Mohamed Samir El-Robh and David C Grainger and Wenke Zhang and Panos Soultanas and Stephen J W Busby},
  booktitle={Nucleic acids research},
  year={2008}
}
The Escherichia coli MelR protein is a transcription activator that autoregulates its own promoter by repressing transcription initiation. Optimal repression requires MelR binding to a site that overlaps the melR transcription start point and to upstream sites. In this work, we have investigated the different determinants needed for optimal repression and their spatial requirements. We show that repression requires a complex involving four DNA-bound MelR molecules, and that the global CRP… CONTINUE READING
7 Citations
34 References
Similar Papers

Citations

Publications citing this paper.

References

Publications referenced by this paper.
Showing 1-10 of 34 references

Similar Papers

Loading similar papers…