Autoregulation of TDP-43 mRNA levels involves interplay between transcription, splicing, and alternative polyA site selection.

@article{AvendaoVzquez2012AutoregulationOT,
  title={Autoregulation of TDP-43 mRNA levels involves interplay between transcription, splicing, and alternative polyA site selection.},
  author={S. Er{\'e}ndira Avenda{\~n}o-V{\'a}zquez and Ashish Dhir and Sara Bembich and Emanuele Buratti and Nicholas Proudfoot and Francisco E. Baralle},
  journal={Genes & development},
  year={2012},
  volume={26 15},
  pages={1679-84}
}
TDP-43 is a critical RNA-binding factor associated with pre-mRNA splicing in mammals. Its expression is tightly autoregulated, with loss of this regulation implicated in human neuropathology. We demonstrate that TDP-43 overexpression in humans and mice activates a 3' untranslated region (UTR) intron, resulting in excision of the proximal polyA site (PAS) pA(1). This activates a cryptic PAS that prevents TDP-43 expression through a nuclear retention mechanism. Superimposed on this process… CONTINUE READING