Autoregulation of Neurogenesis by GDF11

@article{Wu2003AutoregulationON,
  title={Autoregulation of Neurogenesis by GDF11},
  author={Hsiao-Huei Wu and Sanja Ivkovi{\'c} and Richard C. Murray and Sylvia Jaramillo and Karen M. Lyons and Jane E. Johnson and Anne L. Calof},
  journal={Neuron},
  year={2003},
  volume={37},
  pages={197-207}
}
Activin and GDF11 collaborate in feedback control of neuroepithelial stem cell proliferation and fate
TLDR
The data indicate that the transition between stem cells and committed progenitors is neither sharp nor irreversible and that GDF11, ACTβB and FST are crucial components of a circuit that controls both total cell number and the ratio of neuronal versus glial cells in this system.
GDF11 expressed in the adult brain negatively regulates hippocampal neurogenesis
TLDR
Depletion of Gdf11 during adulthood increased proliferation of neural progenitors and decreased the number of newborn neurons in the hippocampus, suggesting that endogenous GDF11 remains a negative regulator of hippocampal neurogenesis in adult mice, and further support the idea that circulating systemic GDF 11 and endogenously expressed GDF12 in the adult brain have different target cells or mechanisms of action.
GDF11 Controls the Timing of Progenitor Cell Competence in Developing Retina
TLDR
It is shown that a secreted factor, growth and differentiation factor 11 (GDF11), controls the numbers of retinal ganglion cells (RGCs), as well as amacrine and photoreceptor cells, that form during development.
Foxg1 promotes olfactory neurogenesis by antagonizing Gdf11
TLDR
It is shown that Foxg1 is expressed in developing OE at the same time as the gene encoding growth differentiation factor 11 (Gdf11), a TGFβ family member that mediates negative-feedback control of OE neurogenesis.
Olfactory epithelium progenitors: insights from transgenic mice and in vitro biology
TLDR
It is shown how recent advances in mouse transgenesis, and in the development of in vitro assays of progenitor activity, have helped to demonstrate the existence of multiple classes of olfactory mucosa-based progenitors.
Gdf11 Facilitates Temporal Progression of Neurogenesis in the Developing Spinal Cord
TLDR
A model in which Gdf11 secreted by newly born neurons in the developing spinal cord facilitates the temporal progression of neurogenesis by acting as a positive feedback signal on the progenitor cells to promote cell cycle exit and decrease proliferation ability, thus changing their differentiation potential is supported.
Molecular Signals Regulating Proliferation of Stem and Progenitor Cells in Mouse Olfactory Epithelium
TLDR
The results indicate that regulation of olfactory neurogenesis is critically dependent on multiple signaling molecules from two different polypeptide growth factor superfamilies, the fibroblast growth factors and the transforming growth factor β (TGF-β) group.
Antagonism between Gdf6a and retinoic acid pathways controls timing of retinal neurogenesis and growth of the eye in zebrafish
TLDR
Results support a model in which dorsally expressed gdf6a limits RA pathway activity to control the transition from proliferation to differentiation in the growing eye, thereby regulating eye size in the vertebrate eye.
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  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
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TLDR
It is suggested that differentiated neurons provide a signal that feeds back to inhibit production of new neurons by their own progenitors, and that stroma-derived factors are important in supporting neurogenesis by this cell.
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