Autoregulation of Neurogenesis by GDF11

@article{Wu2003AutoregulationON,
  title={Autoregulation of Neurogenesis by GDF11},
  author={Hsiao-Huei Wu and Sanja Ivkovi{\'c} and Richard C. Murray and Sylvia Jaramillo and Karen M. Lyons and Jane E. Johnson and Anne L. Calof},
  journal={Neuron},
  year={2003},
  volume={37},
  pages={197-207}
}
In the olfactory epithelium (OE), generation of new neurons by neuronal progenitors is inhibited by a signal from neurons themselves. Here we provide evidence that this feedback inhibitory signal is growth and differentiation factor 11 (GDF11). Both GDF11 and its receptors are expressed by OE neurons and progenitors, and GDF11 inhibits OE neurogenesis in vitro by inducing p27(Kip1) and reversible cell cycle arrest in progenitors. Mice lacking functional GDF11 have more progenitors and neurons… 
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References

SHOWING 1-10 OF 122 REFERENCES
BMPs inhibit neurogenesis by a mechanism involving degradation of a transcription factor
TLDR
A novel mechanism of BMP action is suggested, whereby the induced degradation of an essential transcription factor results in premature termination of a neuronal lineage.
Genesis of olfactory receptor neurons in vitro: Regulation of progenitor cell divisions by fibroblast growth factors
TLDR
The data suggest that FGFs delay differentiation of a committed neuronal transit amplifying cell (the INP) and support proliferation or survival of a rare cell, possibly a stem cell, that acts as a progenitor to INPs.
Neurogenesis and cell death in olfactory epithelium.
TLDR
In vivo surgical studies, which have shown that all cell types in the neuronal lineage of the OE undergo apoptotic cell death, support the idea that these multiple developmental stages may serve as control points at which cell number is regulated by extrinsic factors.
Analysis of neurogenesis in a mammalian neuroepithelium: Proliferation and differentiation of an olfactory neuron precursor in vitro
TLDR
Development of a culture system for mammalian olfactory epithelium has permitted the process of neurogenesis to be examined in vitro, and data are presented which suggest that the precursor follows a simple lineage program, dividing to give rise to two N-CAM+ daughter neurons.
Opposing effects of bone morphogenetic proteins on neuron production and survival in the olfactory receptor neuron lineage.
TLDR
Findings indicate that BMPs exert both positive and negative effects on neurogenesis, depending on ligand identity, ligand concentration and the particular cell in the lineage that is responding, and reveal the presence of a factor or factors, produced by OE stroma, that can synergize with BMP4 to stimulate OE Neurogenesis.
Progenitor cells of the olfactory receptor neuron lineage
The olfactory epithelium of the mouse has many properties that make it an ideal system for studying the molecular regulation of neurogenesis. We have used a combination of in vitro and in vivo
Cell cycle regulation during mouse olfactory neurogenesis.
TLDR
The present data suggest distinct functions for CDK inhibitors, either in the control of cell cycle exit and differentiation during neurogenesis or in the maintenance of a quiescent state in neural progenitors or neurons in adults.
The neuronal stem cell of the olfactory epithelium.
TLDR
These studies suggest that OE neuronal progenitors-which are in close physical proximity to ORNs-can "read" the number of differentiated neurons in their environment and regulate production of new neurons accordingly.
Mash1 activates a cascade of bHLH regulators in olfactory neuron progenitors.
TLDR
The results demonstrate that Mash1 is required at an early stage in the olfactory neuron lineage to initiate a differentiation program involving Math4C/neurogenin1 and NeuroD, another gene activates a similar program in a separate population of ofactory neuron progenitors.
Colony-forming progenitors from mouse olfactory epithelium: evidence for feedback regulation of neuron production.
  • J. Mumm, J. Shou, A. Calof
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 1996
TLDR
It is suggested that differentiated neurons provide a signal that feeds back to inhibit production of new neurons by their own progenitors, and that stroma-derived factors are important in supporting neurogenesis by this cell.
...
1
2
3
4
5
...