Autoregulation of E-cadherin expression by cadherin–cadherin interactions

  title={Autoregulation of E-cadherin expression by cadherin–cadherin interactions},
  author={Maralice Conacci-Sorrell and Inbal Simcha and Tamar Ben-Yedidia and Janna Blechman and Pierre Savagner and Avri Ben-Ze'ev},
  journal={The Journal of Cell Biology},
  pages={847 - 857}
Transcriptional repression of E-cadherin, characteristic of epithelial to mesenchymal transition, is often found also during tumor cell invasion. At metastases, migratory fibroblasts sometimes revert to an epithelial phenotype, by a process involving regulation of the E-cadherin-beta-catenin complex. We investigated the molecular basis of this regulation, using human colon cancer cells with aberrantly activated beta-catenin signaling. Sparse cultures mimicked invasive tumor cells, displaying… CONTINUE READING
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