Autoregulation of Cell-specific MAP Kinase Control of the Tryptophan Hydroxylase Promoter*

@article{Wood2001AutoregulationOC,
  title={Autoregulation of Cell-specific MAP Kinase Control of the Tryptophan Hydroxylase Promoter*},
  author={J. L. Wood and A. Russo},
  journal={The Journal of Biological Chemistry},
  year={2001},
  volume={276},
  pages={21262 - 21271}
}
The neurotransmitter serotonin controls a wide range of biological systems, including its own synthesis and release. As the rate-limiting enzyme in serotonin biosynthesis, tryptophan hydroxylase (TPH) is a potential target for this autoregulation. Using the serotonergic neuron-like CA77 cell line, we have demonstrated that treatment with a 5-hydroxytryptamine autoreceptor agonist, CGS 12066A, can lower TPH mRNA levels and promoter activity. We reasoned that this repression might involve… Expand
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