Autoreactive thymic B cells are efficient antigen-presenting cells of cognate self-antigens for T cell negative selection.

@article{Perera2013AutoreactiveTB,
  title={Autoreactive thymic B cells are efficient antigen-presenting cells of cognate self-antigens for T cell negative selection.},
  author={Jason Perera and Liping Meng and Fanling Meng and Haochu Huang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 42},
  pages={17011-6}
}
The thymus contains a population of B cells that colocalize with dendritic cells and medullary thymic epithelial cells in the thymic medulla. The development and functional significance of these cells are largely unknown. Using recombination-activating gene 2 GFP reporter mice along with parabiosis experiments, we demonstrate that the vast majority of thymic B cells develop from progenitors within the thymus. Thymic B cells express unique phenotypic markers compared with peripheral B cells… CONTINUE READING

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T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse

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