Autoreactive murine Th1 and Th2 cells kill syngeneic macrophages and induce autoantibodies.

@article{Yung2001AutoreactiveMT,
  title={Autoreactive murine Th1 and Th2 cells kill syngeneic macrophages and induce autoantibodies.},
  author={Raymond L. Yung and Michael R. Kaplan and Donna D Ray and Katrin Esther Schneider and Ru Ran Mo and Kirk Johnson and Bruce C. Richardson},
  journal={Lupus},
  year={2001},
  volume={10 8},
  pages={
          539-46
        }
}
D10 cells, a cloned Th2 line, become autoreactive following treatment with DNA methylation inhibitors like 5-azacytidine (5-azaC), and induce anti-DNA antibodies if injected into unirradiated syngenic mice. The mechanism by which the autoreactive cells break tolerance is unknown. To further define effector functions required, we asked if 5-azaC-treated Th1 cells could also induce autoimmunity. AE7 cells, a cloned Th1 line, were treated with 5-azaC and shown to become autoreactive and induce… CONTINUE READING
BETA

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 13 CITATIONS

Similar Papers

Loading similar papers…