Autoreactive anti-DNA transgenic B cells in lupus-prone New Zealand black/New Zealand white mice show near perfect L chain allelic exclusion.

Abstract

Recent work on B cell tolerance and autoimmunity has suggested the L chain allelic inclusion is a property of autoreactive B cells and is closely linked to receptor editing. Allelic inclusion could rescue autoreactive B cells from clonal deletion by reducing their effective BCR surface density. We have investigated this phenomenon in anti-DNA producing… (More)
DOI: 10.4049/jimmunol.0803610

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@article{Makdasi2009AutoreactiveAT, title={Autoreactive anti-DNA transgenic B cells in lupus-prone New Zealand black/New Zealand white mice show near perfect L chain allelic exclusion.}, author={Efi Makdasi and Ruth Fischel and Inbal Kat and Dan Eilat}, journal={Journal of immunology}, year={2009}, volume={182 10}, pages={6143-8} }