Autoreactive T cells to platelet GPIIb-IIIa in immune thrombocytopenic purpura. Role in production of anti-platelet autoantibody.

@article{Kuwana1998AutoreactiveTC,
  title={Autoreactive T cells to platelet GPIIb-IIIa in immune thrombocytopenic purpura. Role in production of anti-platelet autoantibody.},
  author={Masataka Kuwana and Junichi Kaburaki and Yasuo Ikeda},
  journal={The Journal of clinical investigation},
  year={1998},
  volume={102 7},
  pages={1393-402}
}
T cell proliferative responses to platelet membrane GPIIb-IIIa were examined in 14 patients with chronic immune thrombocytopenic purpura (ITP), 7 systemic lupus erythematosus (SLE) patients with or without thrombocytopenia, and 10 healthy donors. Although peripheral blood T cells from all subjects failed to respond to the protein complex in its native state, reduced GPIIb-IIIa stimulated T cells from three ITP patients and one SLE patient with thrombocytopenia, and tryptic peptides of GPIIb… CONTINUE READING

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T–B cell collaboration is essential for the autoantibody response to DNA topoisomerase I in systemic sclerosis

  • M. Kuwana, T. A. Medsger, Jr., T. M. Wright
  • J. Immunol
  • 1995
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