Autoreactive T cells in the immune pathogenesis of pemphigus vulgaris.

@article{Amber2013AutoreactiveTC,
  title={Autoreactive T cells in the immune pathogenesis of pemphigus vulgaris.},
  author={Kyle T. Amber and Patrick Staropoli and Michael I Shiman and George W Elgart and Michael Hertl},
  journal={Experimental dermatology},
  year={2013},
  volume={22 11},
  pages={699-704}
}
Pemphigus vulgaris is a life-threatening autoimmune blistering disease caused by anti-desmoglein IgG autoantibodies that finally lead to acantholysis presenting clinically as progressive blistering. Whilst the production of pathogenic antibodies is key to the development of pemphigus vulgaris, many immunological steps are required prior to autoantibody induction. We review advances in the understanding of these immunologic processes with a focus on human leucocyte antigen polymorphisms and… CONTINUE READING
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Epub ahead of print] 39 Wada N, Nishifuji K, Yamada T et al

  • Dermatol Res
  • J Invest
  • 2013

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