Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication.

Abstract

Antibodies against nuclear self-antigens are characteristic of systemic autoimmunity, although mechanisms promoting their generation and selection are unclear. Here, we report that B cells containing the Y-linked autoimmune accelerator (Yaa) locus are intrinsically biased toward nucleolar antigens because of increased expression of TLR7, a single-stranded… (More)

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@article{Pisitkun2006AutoreactiveBC, title={Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication.}, author={Prapaporn Pisitkun and Jonathan A. Deane and Michael J. Difilippantonio and Tatyana N. Tarasenko and Anne B. Satterthwaite and Silvia M Bolland}, journal={Science}, year={2006}, volume={312 5780}, pages={1669-72} }