Autoradiographic localization of substance P binding sites in guinea-pig airways.

@article{Hoover1987AutoradiographicLO,
  title={Autoradiographic localization of substance P binding sites in guinea-pig airways.},
  author={Donald B. Hoover and John C. Hancock},
  journal={Journal of the autonomic nervous system},
  year={1987},
  volume={19 2},
  pages={171-4}
}
The distribution of substance P (SP) binding sites in guinea-pig airway was examined by in vitro autoradiography with tritium- and iodine-labeled SP. Specific SP binding sites were most abundant in tracheobronchial smooth muscle but were also detected in the mucosa/submucosa. Binding within the mucosa/submucosa was especially high in the region of glands. Binding of iodine-labeled SP to cartilage was negligible. Tritium-labeled SP bound non-specifically to airway cartilage. These observations… CONTINUE READING

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