Autoradiographic localization of D1 and D2 dopamine receptors in the human brain.

@article{Keyser1988AutoradiographicLO,
  title={Autoradiographic localization of D1 and D2 dopamine receptors in the human brain.},
  author={Jacques de Keyser and Anje Claeys and Jean Paul De Backer and Guy Ebinger and Frank Roels and Georges Vauquelin},
  journal={Neuroscience letters},
  year={1988},
  volume={91 2},
  pages={142-7}
}
The distribution of dopamine D1 and D2 receptors in several human brain regions was investigated using autoradiography with the radioligands [3H]SCH 23390 and [3H]spiroperidol. The highest densities of both dopamine receptor types are seen in the nucleus caudatus, putamen and nucleus accumbens. Whereas the density of the D2 receptors is similar in the two segments of the globus pallidus, the pars medialis of the globus pallidus contains a three-fold higher concentration of D1 receptors than the… CONTINUE READING

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