Autoradiographic localization of 5-HT1A receptors in the post-mortem human brain using [3H]WAY-100635 and [11C]WAY-100635

@article{Hall1997AutoradiographicLO,
  title={Autoradiographic localization of 5-HT1A receptors in the post-mortem human brain using [3H]WAY-100635 and [11C]WAY-100635},
  author={H{\aa}kan Hall and Camilla Lundkvist and Christer Halldin and Lars Farde and Victor W. Pike and Julie A. McCarron and Allan Fletcher and Ian Anthony Cliffe and Tjeerd Andries Barf and H{\aa}kan V. Wikstr{\"o}m and G{\"o}ran Sedvall},
  journal={Brain Research},
  year={1997},
  volume={745},
  pages={96-108}
}
The distribution of 5-HT1A receptors was examined in the post-mortem human brain using whole hemisphere autoradiography and the selective 5-HT1A receptor antagonist [3H]WAY-100635 ([O-methyl-3H]-N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2- pyridinyl)cyclohexanecarboxamide trihydrochloride). The autoradiograms showed very dense binding to hippocampus, raphe nuclei and neocortex. The labeling in neocortex was slightly lower than in the hippocampus and was mainly at superficial layers… Expand
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