Autoradiographic evidence for the localization of high affinity neurotensin binding sites on dopaminergic nerve terminals in the nigrostriatal and mesolimbic pathways in rat brain.

@article{Schotte1989AutoradiographicEF,
  title={Autoradiographic evidence for the localization of high affinity neurotensin binding sites on dopaminergic nerve terminals in the nigrostriatal and mesolimbic pathways in rat brain.},
  author={Alain Schotte and Jos{\'e}e E. Leysen},
  journal={Journal of chemical neuroanatomy},
  year={1989},
  volume={2 5},
  pages={253-7}
}
Monoiodo[125I]Tyr3-neurotensin binding in coronal and sagittal brain sections from rats that had received a unilateral 6-hydroxydopamine lesion of the median forebrain bundle, revealed a complete loss of neurotensin binding (NTH)-sites in the caudate nucleus of the lesioned side. Moreover, in the lesioned side, 83% of the NTH-sites disappeared also from the nucleus accumbens and 65% from the olfactory tubercle. NTH-sites subsisted partly in the Islands of Calleja and no significant alteration… CONTINUE READING