Autoradiographic distribution of multiple classes of opioid receptor binding sites in human forebrain.

@article{Pilapil1987AutoradiographicDO,
  title={Autoradiographic distribution of multiple classes of opioid receptor binding sites in human forebrain.},
  author={Carmencita Pilapil and Sandra L Welner and Jacques Magnan and Sylvain Gauthier and R{\'e}mi Quirion},
  journal={Brain research bulletin},
  year={1987},
  volume={19 5},
  pages={611-5}
}
Receptor binding parameters and autoradiographic distribution of various opioid receptor sites have been investigated in normal human brain, post-mortem. [3H]DAGO, a highly selective mu ligand, binds to a single class of high affinity (Kd = 1.1 nM), low capacity (Bmax = 160 fmol/mg protein) sites in membrane preparations of frontal cortex. These sites show a ligand selectivity profile that resembles that of the mu opioid receptor. On the other hand, [3H]bremazocine, in presence of saturating… CONTINUE READING

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