Autoradiographic distribution in rat tissues of binding sites for endothelin: a neuropeptide?

@article{Koseki1989AutoradiographicDI,
  title={Autoradiographic distribution in rat tissues of binding sites for endothelin: a neuropeptide?},
  author={Chizuko Koseki and Masashi Imai and Yukio Hirata and Masashi Yanagisawa and Tomoh Masaki},
  journal={The American journal of physiology},
  year={1989},
  volume={256 4 Pt 2},
  pages={R858-66}
}
Endothelin (ET) is a potent and long-acting vasoconstrictor peptide consisting of 21 amino acids and recently isolated from a medium of cultured porcine endothelial cells. To determine the possible sites of ET action, we have conducted autoradiography and receptor binding assays with 125I-labeled ET in rat tissues. The displaceable binding sites of the ligand were widely distributed, not only in the arteries and heart but also in various other organs, e.g., brain, kidney, lung, adrenal gland… CONTINUE READING

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