Autoradiographic and histological studies of postnatal neurogenesis. I. A longitudinal investigation of the kinetics, migration and transformation of cells incoorporating tritiated thymidine in neonate rats, with special reference to postnatal neurogenesis in some brain regions

@article{Altman1966AutoradiographicAH,
  title={Autoradiographic and histological studies of postnatal neurogenesis. I. A longitudinal investigation of the kinetics, migration and transformation of cells incoorporating tritiated thymidine in neonate rats, with special reference to postnatal neurogenesis in some brain regions},
  author={Joseph Altman and Gopal D. Das},
  journal={Journal of Comparative Neurology},
  year={1966},
  volume={126}
}
Neonate rats were injected systemically with thymidine‐H3 and killed after different periods of survival. Cell proliferation, migration and transformation in the brain were studied autoradiographically. It was established that cells multiplying in the ependymal and subependymal walls of the olfactory ventricle migrate outward into the olfactory bulb, where they become differentiated into granule cells. These postnatally formed granule cells contribute to the formation of the granular and… 
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Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb
  • J. Altman
  • Biology
    The Journal of comparative neurology
  • 1969
TLDR
The results established that the major target structure of cell production in the subependymal layer of the lateral ventricle in young‐adult rats is the olfactory bulb, with only moderate contribution made to the anterior neocortex and basal ganglia.
The Discovery of Adult Mammalian Neurogenesis
TLDR
Behavior tests established that “degranulated” rats displayed abnormalities comparable to those following extensive hippocampal lesions, and it was shown that the granule cells of the olfactory bulb are generated in the persisting subependymal layer of the anterior forebrain and migrate to the ofactory bulb by way of a hitherto unidentified structure, the rostral migratory stream.
Postnatal development of the cerebellar cortex in the rat. I. The external germinal layer and the transitional molecular layer
  • J. Altman
  • Biology
    The Journal of comparative neurology
  • 1972
TLDR
The multiplication of cells in the proliferative zone of the external germinal layer and the early steps in the differentiation of basket, stellate and granule cells were studied in the cerebellar cortex of rats with histological, histochemical, autoradiographic and electron microscopic techniques.
Morphology and distribution of postnatally generated glial cells in the somatosensory cortex of the rat: an autoradiographic and electron microscopic study.
Development of granule cells of the rat olfactory bulb: an autoradiographic and electron microscopic study.
TLDR
Golgi-electron microscopic as well as routine electron microscopic studies on migrating granule cells revealed that centrioles and Golgi apparatus were located at the base of the leading process that possesses a growth cone at its tip.
Studies on the transplantation of developing neural tissue in the mammalian brain. I. Transplantation of cerebellar slabs into the cerebellum of neonate rats.
Autoradiographic study of histogenesis in the mouse olfactory bulb I. Time of origin of neurons and neuroglia
  • J. Hinds
  • Biology
    The Journal of comparative neurology
  • 1968
TLDR
The results support the concept that some germinal layers of the central nervous system are programmed to produce a succession of cell types, larger cells before smaller ones, as in the olfactory formation.
Postnatal Development of the Hippocampal Dentate Gyrus Under Normal and Experimental Conditions
TLDR
The authors do not as yet have an adequate explanation of the delayed formation of microneurons but the importance of these elements in the maturation of brain functions is indicated by behavioral studies.
Thyroid hormone and development of the rat hippocampus: Cell acquisition in the dentate gyrus
Development of astroglial cells in the proliferative matrices, the granule cell layer, and the hippocampal fissure of the hamster dentate gyrus
TLDR
These findings indicate that the dentate matrices not only produce neurons of the stratum granulosum, but also provide a separate population of “secondary” radial glial cells which organizes the glio‐neuronal aggregation of the primordial granule cell layer.
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