Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats

@article{Altman1965AutoradiographicAH,
  title={Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats},
  author={Joseph Altman and Gopal D. Das},
  journal={Journal of Comparative Neurology},
  year={1965},
  volume={124}
}
Key ResultIn the autoradiograms of young rats injected with thymidine-H3 many of the granule cells of the dentate gyrus were found labeled. The number of labeled cells declined rapidly with increased age at the time of injection. Histological studies showed the presence in young rats of a large germinal matrix of mitotic cells in the ependymal and subependymal layers of the third and lateral ventricles.
Autoradiographic and histological studies of post-natal neurogenesis IV
TLDR
The results established that the major target structure of cell production in the subependymal layer of the lateral ventricle in young-adult rats is the olfactory bulb, with only moderate contribution made to the anterior neocortex and basal ganglia.
Autoradiographic and histological studies of postnatal neurogenesis. I. A longitudinal investigation of the kinetics, migration and transformation of cells incoorporating tritiated thymidine in neonate rats, with special reference to postnatal neurogenesis in some brain regions
TLDR
It was established that cells multiplying in the ependymal and subependymal walls of the Olfactory ventricle migrate outward into the olfactory bulb, where they become differentiated into granule cells, and, to a lesser extent, other types of nerve cells of the cerebellar cortex.
The Discovery of Adult Mammalian Neurogenesis
TLDR
Behavior tests established that “degranulated” rats displayed abnormalities comparable to those following extensive hippocampal lesions, and it was shown that the granule cells of the olfactory bulb are generated in the persisting subependymal layer of the anterior forebrain and migrate to the ofactory bulb by way of a hitherto unidentified structure, the rostral migratory stream.
Postnatal neurogenesis in the dentate gyrus of the guinea pig
TLDR
The present data show that, although the guinea pig dentate gyrus develops largely before birth, the production of new neurons continues at a high rate during the first postnatal month, leading to a considerable increase in cell number.
Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation
TLDR
It is confirmed that in the adult rat brain, neuronal progenitor cells divide at the border between the hilus and the granule cell layer (GCL) and in adult rats, the progeny of these cells migrate into the GCL and express the neuronal markers NeuN and calbindin-D28k.
Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb
  • J. Altman
  • Biology
    The Journal of comparative neurology
  • 1969
TLDR
The results established that the major target structure of cell production in the subependymal layer of the lateral ventricle in young‐adult rats is the olfactory bulb, with only moderate contribution made to the anterior neocortex and basal ganglia.
Dynamics of neurogenesis in the dentate gyrus of adult rats
Migration and distribution of two populations of hippocampal granule cell precursors during the perinatal and postnatal periods
TLDR
It is postulated that the great increase in granule cell population during the infantile period is principally due to cells derived from this intrinsic matrix of the dentate gyrus.
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