Autoradiographic analysis of neuropeptide Y receptor binding sites in the rat hippocampus after kainic acid-induced limbic seizures

@article{Rder1996AutoradiographicAO,
  title={Autoradiographic analysis of neuropeptide Y receptor binding sites in the rat hippocampus after kainic acid-induced limbic seizures},
  author={Christine R{\"o}der and Christoph Schwarzer and Annamaria Vezzani and Marco Gobbi and Tiziana Mennini and G{\"u}nther Sperk},
  journal={Neuroscience},
  year={1996},
  volume={70},
  pages={47-55}
}
Changes in peptide YY receptor binding were investigated at various intervals after limbic seizures induced in rats by an intraperitoneal injection of kainic acid (10-12 mg/kg). Six to 24 h after kainic acid, specific peptide YY binding, representing Y1 and Y2 neuropeptide Y receptor subtypes, was markedly enhanced in the strata radiatum and oriens CA3 (increase by up to 185% and 178% of control values, respectively). Seven and 30 days after kainic acid, a reduction by up to 63% was found. The… CONTINUE READING
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