Autoradiographic analysis of mouse brain kinin B1 and B2 receptors after closed head trauma and ability of Anatibant mesylate to cross the blood-brain barrier.

@article{Ongali2006AutoradiographicAO,
  title={Autoradiographic analysis of mouse brain kinin B1 and B2 receptors after closed head trauma and ability of Anatibant mesylate to cross the blood-brain barrier.},
  author={Brice Ongali and Farida Hellal and Donata Rodi and Michel Plotkine and Catherine Marchand-Verrecchia and Didier Pruneau and R{\'e}jean Couture},
  journal={Journal of neurotrauma},
  year={2006},
  volume={23 5},
  pages={696-707}
}
The potent non-peptide B2 receptor (R) antagonist, Anatibant mesylate (Ms) (LF 16-0687 Ms), reduces brain edema and improves neurological function recovery in various focal and diffuse models of traumatic brain injury in rodents. In the present study, alteration of kinin B1 and B2R after closed head trauma (CHT) and in vivo binding properties of Anatibant Ms (3 mg/kg, s.c.) injected 30 min after CHT were studied in mice by autoradiography using the radioligands [125I]HPP-Hoe 140 (B2R), and… CONTINUE READING