Autoproteolytic fragments are intermediates in the oligomerization/aggregation of the Parkinson's disease protein alpha-synuclein as revealed by ion mobility mass spectrometry.

@article{Vlad2011AutoproteolyticFA,
  title={Autoproteolytic fragments are intermediates in the oligomerization/aggregation of the Parkinson's disease protein alpha-synuclein as revealed by ion mobility mass spectrometry.},
  author={Camelia Vlad and Kathrin Lindner and Christiaan Karreman and Stefan Schildknecht and Marcel Leist and N. R. Tomczyk and John Rontree and J. U. D. Langridge and Karin M Danzer and Thomas Ciossek and Alina Brindusa Petre and Michael L Gross and Bastian Hengerer and Michael Przybylski},
  journal={Chembiochem : a European journal of chemical biology},
  year={2011},
  volume={12 18},
  pages={
          2740-4
        }
}
Gas-phase protein separation by ion mobility: With its ability to separate the Parkinson's disease protein α-synuclein and its autoproteolytic products-despite the small concentrations of the latter-ion-mobility MS has enabled the characterization of intermediate fragments in in vitro oligomerization-aggregation. In particular, a possible key fragment, the highly aggregating C-terminal fragment, αSyn(72-140), has been revealed. 
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SHOWING 1-10 OF 27 REFERENCES

Cell

  • J R Mazzulli, Y H Xu, +6 authors D Krainc
  • Cell
  • 2011

Anal. Bioanal. Chern . Wilkins, S. Trimpin). Boca Raton

  • M Klo Niecki, A Jablonowska, +18 authors Chern
  • Anal. Bioanal. Chern . Wilkins, S. Trimpin). Boca…
  • 2009

J. Med. Chern

  • G Juszczyk, A Parasc Hiv, +4 authors Przybylski
  • J. Med. Chern
  • 2009

Eur. J. Mass Spectrom

  • A Dam Oc, E Marqu Ardt, +5 authors Przybylski
  • Eur. J. Mass Spectrom
  • 2007

J. Neurosci

  • K M Danzer, D Haasen, +6 authors M Ko Stka
  • J. Neurosci
  • 2007

Pro c. Natl. Acad. Sci

  • B T Ruotolo, S J Hyung, +4 authors Angew Chern
  • Pro c. Natl. Acad. Sci
  • 2007

Bioi

  • Y Kim, J Kim, +4 authors Chern
  • Bioi
  • 2006

Prog. Neurobiol. Curro Opin. Struct. Bioi

  • H Mirzaei, J L Schieler, +6 authors J L Sussman
  • Prog. Neurobiol. Curro Opin. Struct. Bioi
  • 2006

Neuron

  • M S Forman, V M Lee, +6 authors J Zurdo
  • Neuron
  • 2005

Proc. Natl. Acad. Sci. USA 2009

  • I Bharathi, K S Rao, Neurosci Lett, H A Las Huel, J S Wall
  • Proc. Natl. Acad. Sci. USA
  • 2005

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