Autoproteolysis of the SEA module of rMuc3 C-terminal domain modulates its functional composition.

Abstract

rMuc3 is a typical transmembrane mucin and contains a 174 amino acid domain called an SEA module in its C-terminal domain which is cleaved in eukaryotic cells. However, the mechanism by which the rMuc3 SEA module is proteolyzed and its biological significance has to be elucidated. In this study, we showed that the rMuc3 C-terminal domain was cleaved at… (More)
DOI: 10.1016/j.abb.2010.08.013

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