Autoprocessing of the Vibrio cholerae RTX toxin by the cysteine protease domain.

@article{Sheahan2007AutoprocessingOT,
  title={Autoprocessing of the Vibrio cholerae RTX toxin by the cysteine protease domain.},
  author={K Sheahan and Christina L Cordero and Karla J F Satchell},
  journal={The EMBO journal},
  year={2007},
  volume={26 10},
  pages={2552-61}
}
Vibrio cholerae RTX is a large multifunctional bacterial toxin that causes actin crosslinking. Due to its size, it was predicted to undergo proteolytic cleavage during translocation into host cells to deliver activity domains to the cytosol. In this study, we identified a domain within the RTX toxin that is conserved in large clostridial glucosylating toxins TcdB, TcdA, TcnA, and TcsL; putative toxins from V. vulnificus, Yersinia sp., Photorhabdus sp., and Xenorhabdus sp.; and a filamentous… CONTINUE READING