Autopodial development is selectively impaired by misexpression of chordin-like 1 in the chick limb.

Abstract

Chordin-like 1 (CHRDL1) is a secreted bone morphogenetic protein (BMP) antagonist expressed in mesenchymal tissues whose function in development of the skeleton has not been examined in detail. Here we show Chrdl1 is dynamically expressed in the early distal limb bud mesenchyme, with expression becoming downregulated as development proceeds. Chrdl1… (More)
DOI: 10.1016/j.ydbio.2013.06.003

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