Autophosphorylation within the Atg1 activation loop is required for both kinase activity and the induction of autophagy in Saccharomyces cerevisiae.

@article{Yeh2010AutophosphorylationWT,
  title={Autophosphorylation within the Atg1 activation loop is required for both kinase activity and the induction of autophagy in Saccharomyces cerevisiae.},
  author={Yuh-Ying Yeh and Kristie M Wrasman and Paul Herman},
  journal={Genetics},
  year={2010},
  volume={185 3},
  pages={871-82}
}
Autophagy is an evolutionarily conserved degradative pathway that has been implicated in a number of physiological events important for human health. This process was originally identified as a response to nutrient deprivation and is thought to serve in a recycling capacity during periods of nutritional stress. Autophagy activity appears to be highly regulated and multiple signaling pathways are known to target a complex of proteins that contains the Atg1 protein kinase. The data here extend… CONTINUE READING

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