Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities.

@article{Webber2011AutophosphorylationIT,
  title={Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities.},
  author={Philip J. Webber and Archer D Smith and Saurabh Sen and Matthew B. Renfrow and James A. Mobley and A Brian West},
  journal={Journal of molecular biology},
  year={2011},
  volume={412 1},
  pages={94-110}
}
The leucine-rich repeat kinase 2 (LRRK2) protein has both guanosine triphosphatase (GTPase) and kinase activities, and mutation in either enzymatic domain can cause late-onset Parkinson disease. Nucleotide binding in the GTPase domain may be required for kinase activity, and residues in the GTPase domain are potential sites for autophosphorylation, suggesting a complex mechanism of intrinsic regulation. To further define the effects of LRRK2 autophosphorylation, we applied a technique optimal… CONTINUE READING

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