Autophosphorylation as a possible mechanism of calcium/calmodulin-dependent protein kinase II inhibition during ischemia.

@article{Zalewska1996AutophosphorylationAA,
  title={Autophosphorylation as a possible mechanism of calcium/calmodulin-dependent protein kinase II inhibition during ischemia.},
  author={Teresa Zalewska and K Bialynicka-Birula and Krystyna Domanska-Janik},
  journal={Neurochemistry international},
  year={1996},
  volume={28 2},
  pages={175-81}
}
Cardiac arrest induced rat brain ischemia of 15 min duration produces a rapid and profound decrease in activity of calcium/calmodulin stimulated protein kinase (CaM-KII). In contrast to that, the total amount of enzyme protein remains stable as revealed by Western blotting (alpha subunit specific) analysis. Ischemic insult also results in translocation of the enzyme toward plasmatic membranes, reducing its content in soluble (cytosolic) fraction down to 7% with respect to 50% of control. The… CONTINUE READING

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