Autophosphorylation and phosphotransfer in the Bordetella pertussis BvgAS signal transduction cascade.

@article{Uhl1994AutophosphorylationAP,
  title={Autophosphorylation and phosphotransfer in the Bordetella pertussis BvgAS signal transduction cascade.},
  author={MIMDCOMPUTERSA. Uhl and Jeff Miller},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 3},
  pages={1163-7}
}
Expression of adhesins, toxins, and other virulence factors of Bordetella pertussis is under control of the BvgA and BvgS proteins, members of a bacterial two-component signal transduction family. BvgA bears sequence similarity to regulator components, whereas BvgS shows similarity to both sensor and regulator components. BvgA and the cytoplasmic portion of BvgS ('BvgS) were overexpressed and purified. 'BvgS autophosphorylated with the gamma-phosphate from [gamma-32P]ATP and phosphorylated BvgA… CONTINUE READING
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