Autophosphorylated calcium/calmodulin-dependent protein kinase II alpha induced by cerebral ischemia immediately targets and phosphorylates N-methyl-D-aspartate receptor subunit 2B (NR2B) in hippocampus of rats.

@article{Meng2002AutophosphorylatedCP,
  title={Autophosphorylated calcium/calmodulin-dependent protein kinase II alpha induced by cerebral ischemia immediately targets and phosphorylates N-methyl-D-aspartate receptor subunit 2B (NR2B) in hippocampus of rats.},
  author={Fanjie Meng and Guang-yi Zhang},
  journal={Neuroscience letters},
  year={2002},
  volume={333 1},
  pages={59-63}
}
In this article, we investigated the autophosphorylation and translocation of calcium/calmodulin-dependent protein kinase II alpha (CaMKII alpha) in hippocampus during global ischemia. The following results were observed: (1) CaMKII alpha immediately became autophosphorylated after 3 min ischemia, at the same time, there is a dramatic and sustained translocation of CaMKII alpha from cytosolic fraction to synaptic fraction; (2) CaMKII alpha translocated to post-synaptic density and targeted N… CONTINUE READING

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