Autophagy within the antigen donor cell facilitates efficient antigen cross-priming of virus-specific CD8+ T cells

@article{Uhl2009AutophagyWT,
  title={Autophagy within the antigen donor cell facilitates efficient antigen cross-priming of virus-specific CD8+ T cells},
  author={Miriam Uhl and Oliver Kepp and H{\'e}l{\`e}ne Jusforgues-Saklani and J-M Vicencio and Guido Kroemer and Matthew L Albert},
  journal={Cell Death and Differentiation},
  year={2009},
  volume={16},
  pages={991-1005}
}
Cross-presentation of cell-associated antigen is important in the priming of CD8+ T-cell responses to proteins that are not expressed by antigen-presenting cells (APCs). In vivo, dendritic cells are the main cross-presenting APC, and much is known regarding their ability to capture and process cell-associated antigen. In contrast, little is known about the way death effector pathways influence the efficiency of cross-priming. Here, we compared two important mechanisms of programmed cell death… CONTINUE READING
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