Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues.

@article{HernndezGea2012AutophagyRL,
  title={Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues.},
  author={Virginia Hern{\'a}ndez-Gea and Zahra Ghiassi-Nejad and Raphael Rozenfeld and Ronald D. Gordon and Maria Isabel Fiel and Zhenyu Yue and Mark J Czaja and Scott L Friedman},
  journal={Gastroenterology},
  year={2012},
  volume={142 4},
  pages={
          938-46
        }
}
BACKGROUND & AIMS The pathogenesis of liver fibrosis involves activation of hepatic stellate cells, which is associated with depletion of intracellular lipid droplets. When hepatocytes undergo autophagy, intracellular lipids are degraded in lysosomes. We investigated whether autophagy also promotes loss of lipids in hepatic stellate cells to provide energy for their activation and extended these findings to other fibrogenic cells. METHODS We analyzed hepatic stellate cells from C57BL/6 wild… CONTINUE READING
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